Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of Proteins behind BDNF and NGF. It is thought to promote the survival or differentiation of existing and new neurons in the central nervous system and synapses. These functions are thought to be communicated by TrkC, a receptor tryrosine kinase thought induce NT-3-specific signaling. In addition, NT-3 is thought to also bind TrkB and low affinity nerve growth factor receptor (LNGFR). Recombinant NT-3 is a non-glycosylated, non-covalently linked homodimer, containing two 119 amino acid chains, with a total molecular weight of 27.2 kDa.
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