Fibroblast Growth Factors, FGFs, are a 22 member family of Proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic 147 (variant of FGF basic 154) is a critical component in keeping embryonic stem cells undifferentiated in cell culture systems. Recombinant FGF-b 147 (FGF-2) is a non-glycosylated Protein, containing 147 amino acids, and having a molecular mass of 16.5 kDa.
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