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Products Polyclonal Anti-COX2
| Catalogue number: | PA1211 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | PTGS2 |
| Swiss prot: | P35354 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases. |
| References: | 1. Salmenkivi, K.; Haglund, C.; Ristimaki, A.; Arola, J.; Heikkila, P. : Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. J. Clin. Endocr. Metab. 86: 5615-5619, 2001. 2. Liu, C. H.; Chang, S.-H.; Narko, K.; Trifan, O. C.; Wu, M.-T.; Smith, E.; Haudenschild, C.; Lane, T. F.; Hla, T. : Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J. Biol. Chem. 276: 18563-18569, 2001. 3. Wilkinson-Berka, J. L.; Alousis, N. S.; Kelly, D. J.; Gilbert, R. E. : COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity. Invest. Ophthal. Vis. Sci. 44: 974-979, 2003. 4. Brewer, J. A.; Khor, B.; Vogt, S. K.; Muglia, L. M.; Fujiwara, H.; Haegele, K. E.; Sleckman, B. P.; Muglia, L. J. : T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nature Med. 9: 1318-1322, 2003. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human COX-2, different from the related rat sequence by two amino acids. |
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