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SPRTN (SprT-like N-terminal domain ) Blocking Peptide (the middle region of SPRTN)(100ug)

SPRTN (SprT-like N-terminal domain ) Blocking Peptide (the middle region of SPRTN)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-SPRTN Antibody (ARP68995_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP68995
Size: 100ug
Weight: 55kDa
Gene: 83932
Format: Lyophilized powder
Target: SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Alternative names: C1orf124; DDDL1880; PRO4323; Spartan; dJ876B10.3
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