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RRP8 (ribosomal RNA processing 8, methyltransferase, homolog (yeast) ) Blocking Peptide (the N terminal of RRP8)(100ug)

RRP8 (ribosomal RNA processing 8, methyltransferase, homolog (yeast) ) Blocking Peptide (the N terminal of RRP8)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-RRP8 Antibody (ARP68567_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP68567
Size: 100ug
Weight: 50kDa
Gene: 23378
Format: Lyophilized powder
Target: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Alternative names: KIAA0409
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