Reactivities: | Human |
Presku: | AAP67189 |
Size: | 100ug |
Weight: | 91kDa |
Gene: | 114803 |
Format: | Lyophilized powder |
Target: | MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. |
Alternative names: | 2A-DUB; 2ADUB; DKFZp779J1554; DKFZp779J1721; KIAA1915; RP4-592A1.1 |