Reactivities: | Human |
Presku: | AAP67011 |
Size: | 100ug |
Weight: | 59kDa |
Gene: | 80063 |
Format: | Lyophilized powder |
Target: | ATF7IP2 is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can both act as an activator or a repressor depending on the context. ATF7IP2 mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity. |
Alternative names: | FLJ12668; MCAF2 |