Smarcd3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 ) Blocking Peptide (the C terminal of Smarcd3)(100ug)

Supplier: Aviva Systems Biology Incorporated

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Description
Additional Information

This is a synthetic peptide designed for use in combination with anti-Smarcd3 Antibody (ARP58323_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

Reactivities:	Mouse
Presku:	AAPP32933
Size:	100ug
Weight:	55kDa
Gene:	The peptide is characterized by mass spectroscopy
Format:	Lyophilized powder
Target:	Smarcd3 plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. It stimulates nuclear receptor mediated transcription. It belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Alternative names:	1500001J14Rik; 2210409C08Rik; BAF60C