ProteaDetect HtrA1 ELISA

The ProteaDetect HtrA1 ELISA from ProteaImmun GmbH provides a highly sensitive and specific quantitative determination of HtrA1 in serum, tissue (Placenta) and cell culture supernatants.Human HtrA1 protease (previously termed PRSS11) was initially identified in human fibroblasts and belongs to the high temperature requirement factor A (HtrA) family of serine proteases that can be distinguished from other serine proteases by sequence homology, by the presence of a trypsintype protease domain and one or two carboxyterminal PDZ domains and by their oligomeric architecture.The loss of mammalian HtrA activity is correlated with severe diseases, including arthritis, cancer, familial ischemic cerebral small vessel disease and age related macular degeneration, as well as ParkinsonA^