KDELR2 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 ) Blocking Peptide (the C terminal of KDELR2)(100ug)

Supplier: Aviva Systems Biology Incorporated

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Description
Additional Information

This is a synthetic peptide designed for use in combination with anti-KDELR2 Antibody (ARP67598_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

Reactivities:	Human
Presku:	AAP67598
Size:	100ug
Weight:	21kDa
Gene:	11014
Format:	Lyophilized powder
Target:	Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.
Alternative names:	ELP-1; ERD2.2; FLJ45532