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HMGB1 ELISA

HMGB1 ELISA


Supplier: IBL International GmbH
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HMGB1
is a protein that is normally present in the nucleus and cytoplasm of mammalian cells, and is involved in gene transcription as a chromatin binder. It can then either be released passively as a soluble molecule from necrotic cells, or may be actively secreted from inflammatory cells.

Thus, HMGB1 acts as a cytokine, exhibiting similar pro-inflammatory effects as do TNF- and IL-6. Any disease coping with dying, necrotic cells will therefore be involved with HMGB1 in one of these two cases.

IBL offers the only commercial ELISA worldwide for measuring HMGB1.