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ERBB2 Antibody - Mouse Anti Human Herstatin (5ug)

ERBB2 Antibody - Mouse Anti Human Herstatin (5ug)

Supplier: Aviva Systems Biology Incorporated
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Product Introduction: HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
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Presku: OPPA00155
Size: 5ug
Clone: P7H3BV.
Isotype: IgG2b.
Alternative names: NEU; NGL; HER2; TKR1; HER-2; c-erb B2; HER-2/neu; Receptor tyrosine-protein kinase erbB-2; EC; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen.